diff --git a/src/driver.jl b/src/driver.jl
index 950ea272..b1d55d33 100644
--- a/src/driver.jl
+++ b/src/driver.jl
@@ -197,7 +197,7 @@ const __llvm_initialized = Ref(false)
     end
 
     @tracepoint "IR generation" begin
-        ir, compiled = irgen(job)
+        ir, compiled, gv_to_value = irgen(job)
         if job.config.entry_abi === :specfunc
             entry_fn = compiled[job.source].specfunc
         else
@@ -256,6 +256,9 @@ const __llvm_initialized = Ref(false)
                     dyn_ir, dyn_meta = codegen(:llvm, CompilerJob(dyn_job; config))
                     dyn_entry_fn = LLVM.name(dyn_meta.entry)
                     merge!(compiled, dyn_meta.compiled)
+                    if haskey(dyn_meta, :gv_to_value)
+                        merge!(gv_to_value, dyn_meta.gv_to_value)
+                    end    
                     @assert context(dyn_ir) == context(ir)
                     link!(ir, dyn_ir)
                     changed = true
@@ -422,7 +425,7 @@ const __llvm_initialized = Ref(false)
         @tracepoint "verification" verify(ir)
     end
 
-    return ir, (; entry, compiled)
+    return ir, (; entry, compiled, gv_to_value)
 end
 
 @locked function emit_asm(@nospecialize(job::CompilerJob), ir::LLVM.Module,
diff --git a/src/irgen.jl b/src/irgen.jl
index a7c36a60..5149e9f0 100644
--- a/src/irgen.jl
+++ b/src/irgen.jl
@@ -1,7 +1,7 @@
 # LLVM IR generation
 
 function irgen(@nospecialize(job::CompilerJob))
-    mod, compiled = @tracepoint "emission" compile_method_instance(job)
+    mod, compiled, gv_to_value = @tracepoint "emission" compile_method_instance(job)
     if job.config.entry_abi === :specfunc
         entry_fn = compiled[job.source].specfunc
     else
@@ -55,6 +55,11 @@ function irgen(@nospecialize(job::CompilerJob))
         new_name = safe_name(old_name)
         if old_name != new_name
             LLVM.name!(val, new_name)
+            val = get(gv_to_value, old_name, nothing)
+            if val !== nothing
+                delete!(gv_to_value, old_name)
+                gv_to_value[new_name] = val
+            end
         end
     end
 
@@ -120,7 +125,7 @@ function irgen(@nospecialize(job::CompilerJob))
         can_throw(job) || lower_throw!(mod)
     end
 
-    return mod, compiled
+    return mod, compiled, gv_to_value
 end
 
 
diff --git a/src/jlgen.jl b/src/jlgen.jl
index 0d380cbf..0e2f6d3a 100644
--- a/src/jlgen.jl
+++ b/src/jlgen.jl
@@ -766,23 +766,76 @@ function compile_method_instance(@nospecialize(job::CompilerJob))
         cache_gbl = nothing
     end
 
-    if VERSION >= v"1.13.0-DEV.623"
-        # Since Julia 1.13, the caller is responsible for initializing global variables that
-        # point to global values or bindings with their address in memory.
+    # Since Julia 1.13, the caller is responsible for initializing global variables that
+    # point to global values or bindings with their address in memory.
+    # Similarly on previous versions when imaging=true, it is also the caller's responsibility
+    # (see https://github.com/JuliaGPU/GPUCompiler.jl/issues/753), but we can support this on versions
+    # that have HAS_LLVM_GVS_GLOBALS.
+    gvs = nothing
+    inits = nothing
+    @static if VERSION >= v"1.13.0-DEV.623"
         num_gvars = Ref{Csize_t}(0)
         @ccall jl_get_llvm_gvs(native_code::Ptr{Cvoid}, num_gvars::Ptr{Csize_t},
-                               C_NULL::Ptr{Cvoid})::Nothing
+            C_NULL::Ptr{Cvoid}
+        )::Nothing
         gvs = Vector{Ptr{LLVM.API.LLVMOpaqueValue}}(undef, num_gvars[])
         @ccall jl_get_llvm_gvs(native_code::Ptr{Cvoid}, num_gvars::Ptr{Csize_t},
-                               gvs::Ptr{LLVM.API.LLVMOpaqueValue})::Nothing
+            gvs::Ptr{LLVM.API.LLVMOpaqueValue}
+        )::Nothing
+
         inits = Vector{Ptr{Cvoid}}(undef, num_gvars[])
         @ccall jl_get_llvm_gv_inits(native_code::Ptr{Cvoid}, num_gvars::Ptr{Csize_t},
                                     inits::Ptr{Cvoid})::Nothing
+    elseif HAS_LLVM_GVS_GLOBALS
+        if VERSION >= v"1.12.0-DEV.1703"
+            num_gvars = Ref{Csize_t}(0)
+            @ccall jl_get_llvm_gvs(native_code::Ptr{Cvoid}, num_gvars::Ptr{Csize_t},
+                C_NULL::Ptr{Cvoid}
+            )::Nothing
+            gvs = Vector{Ptr{LLVM.API.LLVMOpaqueValue}}(undef, num_gvars[])
+            @ccall jl_get_llvm_gvs_globals(native_code::Ptr{Cvoid}, num_gvars::Ptr{Csize_t},
+                gvs::Ptr{LLVM.API.LLVMOpaqueValue}
+            )::Nothing
+            inits = Vector{Ptr{Cvoid}}(undef, num_gvars[])
+            @ccall jl_get_llvm_gvs(native_code::Ptr{Cvoid}, num_gvars::Ptr{Csize_t},
+                inits::Ptr{Cvoid}
+            )::Nothing
+        else
+            gvs = get_llvm_global_vars(native_code)
+            inits = get_llvm_global_inits(native_code)
+        end
+    end
 
+    # Maintain a map from global variables to their initialized Julia values.
+    # The objects pointed to are perma-rooted, during codegen.
+    # It is legal to call `Base.unsafe_pointer_to_objref` on `values(gv_to_value)`,
+    # but x->pointer_from_objref(Base.unsafe_pointer_to_objref(x)) is not idempotent,
+    # thus we store raw pointers here.
+    # Currently GVs are privatized, so users may have to handle embedded pointers,
+    # but this dictionary provides a clear indication that the embedded pointer is
+    # indeed avalid Julia object.
+    gv_to_value = Dict{String, Ptr{Cvoid}}()
+
+    # On certain version of Julia we have no reliable way to match the `gvs` to their initializers `inits`.
+    if gvs === nothing
+        # global variables here properly.
+        for gv in globals(llvm_mod)
+            if !haskey(metadata(gv), "julia.constgv")
+                continue
+            end
+            gv_to_value[LLVM.name(gv)] = C_NULL
+        end
+    else
+        @assert inits !== nothing
         for (gv_ref, init) in zip(gvs, inits)
             gv = GlobalVariable(gv_ref)
-            val = const_inttoptr(ConstantInt(Int64(init)), LLVM.PointerType())
-            initializer!(gv, val)
+            gv_to_value[LLVM.name(gv)] = init
+            # set the initializer
+            # TODO(vc): To enable full relocation we should actually strip out the initializers here.
+            if LLVM.isnull(initializer(gv))
+                val = const_inttoptr(ConstantInt(Int64(init)), LLVM.PointerType())
+                initializer!(gv, val)
+            end
         end
     end
 
@@ -854,7 +907,7 @@ function compile_method_instance(@nospecialize(job::CompilerJob))
     # ensure that the requested method instance was compiled
     @assert haskey(compiled, job.source)
 
-    return llvm_mod, compiled
+    return llvm_mod, compiled, gv_to_value
 end
 
 # partially revert JuliaLangjulia#49391
diff --git a/src/utils.jl b/src/utils.jl
index 095f22dc..674d8f9b 100644
--- a/src/utils.jl
+++ b/src/utils.jl
@@ -182,3 +182,59 @@ function kernels(mod::LLVM.Module)
     end
     return vals
 end
+
+@static if VERSION < v"1.13.0-DEV.623"
+    import Libdl
+
+    const HAS_LLVM_GVS_GLOBALS = Libdl.dlsym(
+        unsafe_load(cglobal(:jl_libjulia_handle, Ptr{Cvoid})), :jl_get_llvm_gvs_globals, throw_error=false) !== nothing
+
+    const AL_N_INLINE = 29
+
+    # Mirrors arraylist_t
+    mutable struct ArrayList
+        len::Csize_t
+        max::Csize_t
+        items::Ptr{Ptr{Cvoid}}
+        _space::NTuple{AL_N_INLINE, Ptr{Cvoid}}
+
+        function ArrayList()
+            list = new(0, AL_N_INLINE, Ptr{Ptr{Cvoid}}(C_NULL), ntuple(_ -> Ptr{Cvoid}(C_NULL), AL_N_INLINE))
+            list.items = Base.pointer_from_objref(list) + fieldoffset(typeof(list), 4)
+
+            finalizer(list) do list
+                if list.items != Base.pointer_from_objref(list) + fieldoffset(typeof(list), 4)
+                    Libc.free(list.items)
+                end
+            end
+            return list
+        end
+    end
+
+    function get_llvm_global_vars(native_code::Ptr{Cvoid})
+        gvs_list = ArrayList()
+        GC.@preserve gvs_list begin
+            p_gvs = Base.pointer_from_objref(gvs_list)
+            @ccall jl_get_llvm_gvs_globals(native_code::Ptr{Cvoid}, p_gvs::Ptr{Cvoid})::Nothing
+            gvs = Vector{Ptr{LLVM.API.LLVMOpaqueValue}}(undef, gvs_list.len)
+            items = Base.unsafe_convert(Ptr{Ptr{LLVM.API.LLVMOpaqueValue}}, gvs_list.items)
+            for i in 1:gvs_list.len
+                gvs[i] = unsafe_load(items, i)
+            end
+        end
+        return gvs
+    end
+
+    function get_llvm_global_inits(native_code::Ptr{Cvoid})
+        inits_list = ArrayList()
+        GC.@preserve inits_list begin
+            p_inits = Base.pointer_from_objref(inits_list)
+            @ccall jl_get_llvm_gvs(native_code::Ptr{Cvoid}, p_inits::Ptr{Cvoid})::Nothing
+            inits = Vector{Ptr{Cvoid}}(undef, inits_list.len)
+            for i in 1:inits_list.len
+                inits[i] = unsafe_load(inits_list.items, i)
+            end
+        end
+        return inits
+    end
+end
diff --git a/test/helpers/native.jl b/test/helpers/native.jl
index d53ff172..656028f4 100644
--- a/test/helpers/native.jl
+++ b/test/helpers/native.jl
@@ -14,8 +14,10 @@ struct CompilerParams <: AbstractCompilerParams
         new(entry_safepoint, method_table)
 end
 
+module Runtime end
+
 NativeCompilerJob = CompilerJob{NativeCompilerTarget,CompilerParams}
-GPUCompiler.runtime_module(::NativeCompilerJob) = TestRuntime
+GPUCompiler.runtime_module(::NativeCompilerJob) = Runtime
 
 GPUCompiler.method_table(@nospecialize(job::NativeCompilerJob)) = job.config.params.method_table
 GPUCompiler.can_safepoint(@nospecialize(job::NativeCompilerJob)) = job.config.params.entry_safepoint
@@ -24,7 +26,7 @@ function create_job(@nospecialize(func), @nospecialize(types);
                     entry_safepoint::Bool=false, method_table=test_method_table, kwargs...)
     config_kwargs, kwargs = split_kwargs(kwargs, GPUCompiler.CONFIG_KWARGS)
     source = methodinstance(typeof(func), Base.to_tuple_type(types), Base.get_world_counter())
-    target = NativeCompilerTarget()
+    target = NativeCompilerTarget(;jlruntime=true)
     params = CompilerParams(entry_safepoint, method_table)
     config = CompilerConfig(target, params; kernel=false, config_kwargs...)
     CompilerJob(source, config), kwargs
diff --git a/test/native.jl b/test/native.jl
index da08764f..83339ea9 100644
--- a/test/native.jl
+++ b/test/native.jl
@@ -36,16 +36,19 @@ end
     @testset "compilation database" begin
         mod = @eval module $(gensym())
             @noinline inner(x) = x+1
-            function outer(x)
-                return inner(x)
+            function outer(x, sym)
+                if sym == :a
+                    return inner(x)
+                end
+                return x
             end
         end
 
-        job, _ = Native.create_job(mod.outer, (Int,))
+        job, _ = Native.create_job(mod.outer, (Int, Symbol))
         JuliaContext() do ctx
-            ir, meta = GPUCompiler.compile(:llvm, job)
+            ir, meta = GPUCompiler.compile(:llvm, job; validate=false)
 
-            meth = only(methods(mod.outer, (Int,)))
+            meth = only(methods(mod.outer, (Int, Symbol)))
 
             mis = filter(mi->mi.def == meth, keys(meta.compiled))
             @test length(mis) == 1
@@ -53,6 +56,16 @@ end
             other_mis = filter(mi->mi.def != meth, keys(meta.compiled))
             @test length(other_mis) == 1
             @test only(other_mis).def in methods(mod.inner)
+
+            if VERSION >= v"1.12"
+                @test length(meta.gv_to_value) == 1
+            end
+            # TODO: Global values get privatized, so we can't find them by name anymore.
+            # %.not = icmp eq ptr %"sym::Symbol", inttoptr (i64 140096668482288 to ptr), !dbg !38
+            # for (name, v) in meta.gv_to_value
+            #     gv = globals(ir)[name]
+            #     @test LLVM.initializer(gv) === v
+            # end
         end
     end
 
diff --git a/test/native/precompile.jl b/test/native/precompile.jl
index 6fe981a5..d4c0a7ac 100644
--- a/test/native/precompile.jl
+++ b/test/native/precompile.jl
@@ -13,12 +13,34 @@ precompile_test_harness("Inference caching") do load_path
             A[1] = x
             return
         end
+             
+        function kernel_w_global(A, x, sym)
+            if sym == :A
+                A[1] = x
+            end
+            return
+        end
+
+        function square(x)
+            return x*x
+        end
 
         let
             job, _ = NativeCompiler.Native.create_job(kernel, (Vector{Int}, Int))
             precompile(job)
         end
 
+        let
+            job, _ = NativeCompiler.Native.create_job(kernel_w_global, (Vector{Int}, Int, Symbol))
+            precompile(job)
+        end
+
+        let
+            # Emit the func abi to box the return
+            job, _ = NativeCompiler.Native.create_job(square, (Float64,), entry_abi=:func)
+            precompile(job)
+        end
+
         # identity is foreign
         @setup_workload begin
             job, _ = NativeCompiler.Native.create_job(identity, (Int,))
@@ -28,7 +50,7 @@ precompile_test_harness("Inference caching") do load_path
         end
     end) |> string)
 
-    Base.compilecache(Base.PkgId("NativeBackend"))
+    Base.compilecache(Base.PkgId("NativeBackend"), stderr, stdout)
     @eval let
         import NativeCompiler
 
@@ -47,6 +69,12 @@ precompile_test_harness("Inference caching") do load_path
         kernel_mi = GPUCompiler.methodinstance(typeof(NativeBackend.kernel), Tuple{Vector{Int}, Int})
         @test check_presence(kernel_mi, token)
 
+        kernel_w_global_mi = GPUCompiler.methodinstance(typeof(NativeBackend.kernel_w_global), Tuple{Vector{Int}, Int, Symbol})
+        @test check_presence(kernel_w_global_mi, token)
+
+        square_mi = GPUCompiler.methodinstance(typeof(NativeBackend.square), Tuple{Float64})
+        @test check_presence(square_mi, token)
+
         # check that identity survived
         @test check_presence(identity_mi, token) broken=VERSION>=v"1.12.0-DEV.1268"
 
diff --git a/test/ptx/precompile.jl b/test/ptx/precompile.jl
index b5f980c9..e0739df0 100644
--- a/test/ptx/precompile.jl
+++ b/test/ptx/precompile.jl
@@ -25,7 +25,7 @@ precompile_test_harness("Inference caching") do load_path
         end
     end) |> string)
 
-    Base.compilecache(Base.PkgId("PTXBackend"))
+    Base.compilecache(Base.PkgId("PTXBackend"), stderr, stdout)
     @eval let
         import PTXCompiler