If there is a large list of CSS, JS, ... files in the TSFE context, an HTTP response code 500 is returned.
The reason is the Response Header Limit (Apache: LimitRequestFields, ...)
We should have the possibility to limit the header link: value list to a maximum of kiloBytes or a maxium of items in the list.
Alternatively, a hook or event would also be possible, so that each extension can intervene there.
We encountered the problem in our local development environment because the CSS and JavaScript components were loaded individually for the source maps instead of combined for staging and production.
At the moment we just don't see any possibility of limiting the HTTP2 resource pusher to that effect.