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[TRE-FX](https://trefx.uk/)is a project [funded](https://dareuk.org.uk/five-projects-funded-to-drive-more-coordinated-secure-use-of-sensitive-data-for-research-across-uk/) by UK Research and Innovation ([UKRI](https://www.ukri.org/)) as part of the [DARE UK](https://dareuk.org.uk/)_Data and Analytics Research Environments UK_ programme ([MC_PC_23007](https://gtr.ukri.org/projects?ref=MC_PC_23007)).
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[TRE-FX](https://trefx.uk/)was a project [funded](https://dareuk.org.uk/five-projects-funded-to-drive-more-coordinated-secure-use-of-sensitive-data-for-research-across-uk/) by UK Research and Innovation ([UKRI](https://www.ukri.org/)) as part of the [DARE UK](https://dareuk.org.uk/)_Data and Analytics Research Environments UK_ programme ([MC_PC_23007](https://gtr.ukri.org/projects?ref=MC_PC_23007)).
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## Motivation
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Trusted research environments (TREs) are secure digital locations in which data are placed for researchers to analyse. They host administrative data, hospital data or any other data that must be securely held and only accessible for approved projects by approved researchers.
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However, it is hard for a researcher to perform analysis across multiple TREs – for example when data is to be analysed across geographical or governance boundaries, such as devolved healthcare data from across different nations of the UK. Yet this ability is urgently needed. Analysis across a federation of TREs would enable timely analysis of data scattered across the UK to answer urgent questions, as we needed in the COVID-19 pandemic.
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The technologies and standards we need to be able to do this are available now – they do not need to be invented. TRE-FX is assembling leading technology providers from ELIXIR-UK and Health Data Research UK (HDR UK) with three TRE providers and two leading analysis platforms.
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The project will show through a real demonstration how we can use secure research objects to move between TREs while still supporting the Five Safes principles that govern and protect sensitive data – all overseen by public representatives. Research objects are a standardised way of describing and packaging the digital information needed (but not the data itself) to pose a research question and report the answer.
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The impact will be a step change for how researchers can safely run analyses across data stored in many locations, and for how data providers from any sector can safely implement this using technology and standards we already have today.
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The project built a demonstration of how we can use secure research objects to move between TREs while still supporting the Five Safes principles that govern and protect sensitive data – all overseen by public representatives. [Research Objects](activities/researchobject/) are a standardised way of describing and packaging the digital information needed (but not the data itself) to pose a research question and report the answer.
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## Approach
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[**TRE-FX**](https://trefx.uk/)is assembling leading technology providers from
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[**TRE-FX**](https://trefx.uk/)assembled leading technology providers from
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[ELIXIR-UK](https://elixiruknode.org/) and [HDR UK](https://www.hdruk.ac.uk/),
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with three TRE providers and two leading analysis platforms
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to show through a real reference implementation how we can use secure Research
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Objects to move between TREs while still supporting the [Five Safes principles](https://ukdataservice.ac.uk/help/secure-lab/what-is-the-five-safes-framework/) that
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govern and protect patient data; all overseen by patient representatives.
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Objects to move between TREs while still supporting the [Five Safes principles](https://ukdataservice.ac.uk/help/secure-lab/what-is-the-five-safes-framework/) that govern and protect patient data; all overseen by patient representatives.
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The impact will be a step change for how researchers can safely combine data from
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many sources, and for how data providers from any sector can safely implement this
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using technology and standards we already have today.
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This is potentially a step change for how researchers can safely combine data from many sources, and for how data providers from any sector can safely implement this using technology and standards we already have today.
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* Principal investigator: Professor Carole Goble, University of Manchester
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* Project partners: University of Manchester, University of Nottingham, University of Dundee, University of Swansea, University of Birmingham, Health Data Research UK (HDR UK), University of Liverpool, Bitfount, Birmingham University Hospitals NHS Trust
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## eScience Lab involvement
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eScience Lab is leading this project on behalf of [ELIXIR-UK](https://elixiruknode.org/), and is mainly contributing to:
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eScience Lab led this project on behalf of [ELIXIR-UK](https://elixiruknode.org/), and mainly contributed to:
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* WP1: PPIE (lead: University of Nottingham / PIONEER)
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- Promote the inclusion of under-represented groups (as required)
@@ -79,5 +74,27 @@ eScience Lab is leading this project on behalf of [ELIXIR-UK](https://elixirukno
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- Publish DataSHIELD and Bitfount WfExS open-source workflow to workflowhub.eu
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- Federated analytic workflows validated on TREs
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*[Slides: TRE-FX: Core federation services for a federated network of TREs to enable Five Safes analytics](https://doi.org/10.5281/zenodo.7708175)
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## Outputs
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Thomas Giles, Stian Soiland-Reyes, Jonathan Couldridge, Stuart Wheater, Blaise Thomson, Jillian Beggs, Suzy Gallier, Sam Cox, Daniel Lea, Justin Biddle, Rima Doal, Naaman Tammuz, Becca Wilson, Christian Cole, Elizabeth Sapey, Simon Thompson, Professor Emily Jefferson, Phillip Quinlan, Carole Goble (2023):
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[**TRE-FX: Delivering a federated network of trusted research environments to enable safe data analytics**](https://doi.org/10.5281/zenodo.10055354).
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_Zenodo_ / DARE UK
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<https://doi.org/10.5281/zenodo.10055354>
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Stian Soiland-Reyes, Stuart Wheater (2023):
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[**Five Safes RO-Crate profile**](https://w3id.org/5s-crate/0.4), version 0.4.
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_TRE-FX Candidate Recommendation_
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<https://w3id.org/5s-crate/0.4>
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Carole Goble, Phil Quinlan, Tom Giles (2023):
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[**TRE-FX: Core federation services for a federated network of TREs to enable Five Safes analytics**](https://doi.org/10.5281/zenodo.7708175)
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_DARE-UK launch_, 2023-03-08.
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<https://doi.org/10.5281/zenodo.7708175>
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Simone Leo, Laura Rodríguez-Navas, José M. Fernández, Paul De Geest, Luca Pireddu, Michael R. Crusoe, Daniel Garijo, Iacopo Colonnelli, Raül Sirvent, Stian Soiland-Reyes (2023):
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[**Making workflow provenance FAIR across workflow systems with Workflow Run RO-Crate**](https://doi.org/10.5281/zenodo.8004793).
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_Elixir All Hands 2023_, 2023-06-06, Dublin, Ireland.
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_BioHackrXiv_
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<https://doi.org/10.37044/osf.io/24jst>
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Carole Goble, Finn Bacall, Stian Soiland-Reyes, Stuart Owen, Ignacio Eguinoa, Bert Droesbeke, Hervé Ménager, Laura Rodriguez-Navas, José M. Fernández, Björn Grüning, Simone Leo, Luca Pireddu, Michael Crusoe, Johan Gustafsson, Salvador Capella-Gutierrez, Frederik Coppens (2023):
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[**EOSC-Life Workflow Collaboratory for the Life Sciences**](https://doi.org/10.52825/cordi.v1i.352).
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1st Conference on Research Data Infrastructure ([CoRDI 2023](https://www.nfdi.de/cordi-2023/)), 2023-09-12/--14, Karlsruhe, Germany.
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_Proceedings of the Conference on Research Data Infrastructure_**1**
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<https://doi.org/10.52825/cordi.v1i.352>
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Leyla Jael Castro, Stian Soiland-Reyes, Dietrich Rebholz-Schuhmann (2023):
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[**RO-Crates Meets FAIR Digital Objects**](https://www.tib-op.org/ojs/index.php/CoRDI/article/view/396/577).
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1st Conference on Research Data Infrastructure ([CoRDI 2023](https://www.nfdi.de/cordi-2023/)), 2023-09-12/--14, Karlsruhe, Germany.
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_Proceedings of the Conference on Research Data Infrastructure_**1**
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<https://doi.org/10.52825/cordi.v1i.396>
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Stian Soiland-Reyes, Carole Goble, Paul Groth (2023):
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[**Evaluating FAIR Digital Object and Linked Data as distributed object systems**](https://s11.no/2023/phd/evaluating-fdo/).
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title: Presentations
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This is a infrequently updated (and incomplete) list of presentation made by the [eScience lab team](../people/).
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## 2023
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*[The Software Sustainability Institute Fellows Community](https://doi.org/10.6084/m9.figshare.22137512) (invited lightning talk), Fellowship Information Session, Netherlands eScience Center, Online, 22 February 2023
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*[The Software Sustainability Institute Community and Events: How the SSI supports research software through community-building and events](https://doi.org/10.6084/m9.figshare.21931299) (contributed talk, [video](https://fosdem.org/2023/schedule/event/openresearch_software_sustainability_institute/)), FOSDEM 2023, ULB, Brussels, Belgium [presented remotely], 4 February 2023
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Peter Sefton, Stian Soiland-Reyes (2023):
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[**Packaging data with detailed metadata using RO-Crate in FAIR open repositories**](https://ptsefton.com/2023/06/13/ro-crate-or-2023/).
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_Open Repositories 2023_ ([OR2023](https://or2023.openrepositories.org)), 2023-06-12/--15, Stellenbosch University, South Africa.
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<https://doi.org/10.5281/zenodo.8091505>
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Carole Goble (2023):
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**The EOSC-Life Workflow Collaboratory for the Life Sciences**.
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_1st Conference on Research Data Infrastructure_ ([CoRDI 2023](https://www.nfdi.de/cordi-2023/)), 2023-09-12/--14, Karlsruhe, Germany.
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<https://doi.org/10.5281/zenodo.8348470>
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## 2022
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* Reproducible and Open Science (invited talk), Jodrell Bank Centre for Astrophysics Autumn Computing Sessions - by Rachael Ainsworth, University of Manchester, Manchester, UK, 3 November 2022
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*[Reproducible and Open Science](https://doi.org/10.6084/m9.figshare.20079179) (invited keynote talk), [ESCAPE Summer School 2022](https://indico.in2p3.fr/event/26913/) - by Rachael Ainsworth, LAPP, Annecy, France [presented remotely], 20 June 2022
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