diff --git a/bigframes/core/compile/sqlglot/expressions/unary_compiler.py b/bigframes/core/compile/sqlglot/expressions/unary_compiler.py
index 98f1603be7..f519aef70d 100644
--- a/bigframes/core/compile/sqlglot/expressions/unary_compiler.py
+++ b/bigframes/core/compile/sqlglot/expressions/unary_compiler.py
@@ -27,6 +27,7 @@
 import bigframes.core.compile.sqlglot.expressions.constants as constants
 from bigframes.core.compile.sqlglot.expressions.op_registration import OpRegistration
 from bigframes.core.compile.sqlglot.expressions.typed_expr import TypedExpr
+import bigframes.dtypes as dtypes
 
 UNARY_OP_REGISTRATION = OpRegistration()
 
@@ -420,7 +421,28 @@ def _(op: ops.base_ops.UnaryOp, expr: TypedExpr) -> sge.Expression:
 
 @UNARY_OP_REGISTRATION.register(ops.IsInOp)
 def _(op: ops.IsInOp, expr: TypedExpr) -> sge.Expression:
-    return sge.In(this=expr.expr, expressions=[sge.convert(v) for v in op.values])
+    values = []
+    is_numeric_expr = dtypes.is_numeric(expr.dtype)
+    for value in op.values:
+        if value is None:
+            continue
+        dtype = dtypes.bigframes_type(type(value))
+        if expr.dtype == dtype or is_numeric_expr and dtypes.is_numeric(dtype):
+            values.append(sge.convert(value))
+
+    if op.match_nulls:
+        contains_nulls = any(_is_null(value) for value in op.values)
+        if contains_nulls:
+            return sge.Is(this=expr.expr, expression=sge.Null()) | sge.In(
+                this=expr.expr, expressions=values
+            )
+
+    if len(values) == 0:
+        return sge.convert(False)
+
+    return sge.func(
+        "COALESCE", sge.In(this=expr.expr, expressions=values), sge.convert(False)
+    )
 
 
 @UNARY_OP_REGISTRATION.register(ops.isalnum_op)
@@ -767,7 +789,7 @@ def _(op: ops.ToTimedeltaOp, expr: TypedExpr) -> sge.Expression:
     factor = UNIT_TO_US_CONVERSION_FACTORS[op.unit]
     if factor != 1:
         value = sge.Mul(this=value, expression=sge.convert(factor))
-    return sge.Interval(this=value, unit=sge.Identifier(this="MICROSECOND"))
+    return value
 
 
 @UNARY_OP_REGISTRATION.register(ops.UnixMicros)
@@ -866,3 +888,9 @@ def _(op: ops.ZfillOp, expr: TypedExpr) -> sge.Expression:
         ],
         default=sge.func("LPAD", expr.expr, sge.convert(op.width), sge.convert("0")),
     )
+
+
+# Helpers
+def _is_null(value) -> bool:
+    # float NaN/inf should be treated as distinct from 'true' null values
+    return typing.cast(bool, pd.isna(value)) and not isinstance(value, float)
diff --git a/tests/system/small/engines/test_generic_ops.py b/tests/system/small/engines/test_generic_ops.py
index 8deef3638e..14c6e9a454 100644
--- a/tests/system/small/engines/test_generic_ops.py
+++ b/tests/system/small/engines/test_generic_ops.py
@@ -392,7 +392,7 @@ def test_engines_invert_op(scalars_array_value: array_value.ArrayValue, engine):
     assert_equivalence_execution(arr.node, REFERENCE_ENGINE, engine)
 
 
-@pytest.mark.parametrize("engine", ["polars", "bq"], indirect=True)
+@pytest.mark.parametrize("engine", ["polars", "bq", "bq-sqlglot"], indirect=True)
 def test_engines_isin_op(scalars_array_value: array_value.ArrayValue, engine):
     arr, col_ids = scalars_array_value.compute_values(
         [
diff --git a/tests/unit/core/compile/sqlglot/expressions/snapshots/test_binary_compiler/test_mul_timedelta/out.sql b/tests/unit/core/compile/sqlglot/expressions/snapshots/test_binary_compiler/test_mul_timedelta/out.sql
index c8a8cf6cbf..f8752d0a60 100644
--- a/tests/unit/core/compile/sqlglot/expressions/snapshots/test_binary_compiler/test_mul_timedelta/out.sql
+++ b/tests/unit/core/compile/sqlglot/expressions/snapshots/test_binary_compiler/test_mul_timedelta/out.sql
@@ -11,7 +11,7 @@ WITH `bfcte_0` AS (
     `bfcol_1` AS `bfcol_8`,
     `bfcol_2` AS `bfcol_9`,
     `bfcol_0` AS `bfcol_10`,
-    INTERVAL `bfcol_3` MICROSECOND AS `bfcol_11`
+    `bfcol_3` AS `bfcol_11`
   FROM `bfcte_0`
 ), `bfcte_2` AS (
   SELECT
diff --git a/tests/unit/core/compile/sqlglot/expressions/snapshots/test_binary_compiler/test_sub_timedelta/out.sql b/tests/unit/core/compile/sqlglot/expressions/snapshots/test_binary_compiler/test_sub_timedelta/out.sql
index 460f941d1b..2d615fcca6 100644
--- a/tests/unit/core/compile/sqlglot/expressions/snapshots/test_binary_compiler/test_sub_timedelta/out.sql
+++ b/tests/unit/core/compile/sqlglot/expressions/snapshots/test_binary_compiler/test_sub_timedelta/out.sql
@@ -11,7 +11,7 @@ WITH `bfcte_0` AS (
     `bfcol_1` AS `bfcol_8`,
     `bfcol_2` AS `bfcol_9`,
     `bfcol_0` AS `bfcol_10`,
-    INTERVAL `bfcol_3` MICROSECOND AS `bfcol_11`
+    `bfcol_3` AS `bfcol_11`
   FROM `bfcte_0`
 ), `bfcte_2` AS (
   SELECT
diff --git a/tests/unit/core/compile/sqlglot/expressions/snapshots/test_unary_compiler/test_is_in/out.sql b/tests/unit/core/compile/sqlglot/expressions/snapshots/test_unary_compiler/test_is_in/out.sql
index 36941df71b..7a1a2a743d 100644
--- a/tests/unit/core/compile/sqlglot/expressions/snapshots/test_unary_compiler/test_is_in/out.sql
+++ b/tests/unit/core/compile/sqlglot/expressions/snapshots/test_unary_compiler/test_is_in/out.sql
@@ -1,13 +1,32 @@
 WITH `bfcte_0` AS (
   SELECT
-    `int64_col` AS `bfcol_0`
+    `int64_col` AS `bfcol_0`,
+    `float64_col` AS `bfcol_1`
   FROM `bigframes-dev`.`sqlglot_test`.`scalar_types`
 ), `bfcte_1` AS (
   SELECT
     *,
-    `bfcol_0` IN (1, 2, 3) AS `bfcol_1`
+    COALESCE(`bfcol_0` IN (1, 2, 3), FALSE) AS `bfcol_2`,
+    (
+      `bfcol_0` IS NULL
+    ) OR `bfcol_0` IN (123456) AS `bfcol_3`,
+    COALESCE(`bfcol_0` IN (1.0, 2.0, 3.0), FALSE) AS `bfcol_4`,
+    FALSE AS `bfcol_5`,
+    COALESCE(`bfcol_0` IN (2.5, 3), FALSE) AS `bfcol_6`,
+    FALSE AS `bfcol_7`,
+    COALESCE(`bfcol_0` IN (123456), FALSE) AS `bfcol_8`,
+    (
+      `bfcol_1` IS NULL
+    ) OR `bfcol_1` IN (1, 2, 3) AS `bfcol_9`
   FROM `bfcte_0`
 )
 SELECT
-  `bfcol_1` AS `int64_col`
+  `bfcol_2` AS `ints`,
+  `bfcol_3` AS `ints_w_null`,
+  `bfcol_4` AS `floats`,
+  `bfcol_5` AS `strings`,
+  `bfcol_6` AS `mixed`,
+  `bfcol_7` AS `empty`,
+  `bfcol_8` AS `ints_wo_match_nulls`,
+  `bfcol_9` AS `float_in_ints`
 FROM `bfcte_1`
\ No newline at end of file
diff --git a/tests/unit/core/compile/sqlglot/expressions/snapshots/test_unary_compiler/test_to_timedelta/out.sql b/tests/unit/core/compile/sqlglot/expressions/snapshots/test_unary_compiler/test_to_timedelta/out.sql
index 01ebebc455..057e6c778e 100644
--- a/tests/unit/core/compile/sqlglot/expressions/snapshots/test_unary_compiler/test_to_timedelta/out.sql
+++ b/tests/unit/core/compile/sqlglot/expressions/snapshots/test_unary_compiler/test_to_timedelta/out.sql
@@ -8,7 +8,7 @@ WITH `bfcte_0` AS (
     *,
     `bfcol_1` AS `bfcol_4`,
     `bfcol_0` AS `bfcol_5`,
-    INTERVAL `bfcol_0` MICROSECOND AS `bfcol_6`
+    `bfcol_0` AS `bfcol_6`
   FROM `bfcte_0`
 ), `bfcte_2` AS (
   SELECT
@@ -16,7 +16,7 @@ WITH `bfcte_0` AS (
     `bfcol_4` AS `bfcol_10`,
     `bfcol_5` AS `bfcol_11`,
     `bfcol_6` AS `bfcol_12`,
-    INTERVAL (`bfcol_5` * 1000000) MICROSECOND AS `bfcol_13`
+    `bfcol_5` * 1000000 AS `bfcol_13`
   FROM `bfcte_1`
 ), `bfcte_3` AS (
   SELECT
@@ -25,7 +25,7 @@ WITH `bfcte_0` AS (
     `bfcol_11` AS `bfcol_19`,
     `bfcol_12` AS `bfcol_20`,
     `bfcol_13` AS `bfcol_21`,
-    INTERVAL (`bfcol_11` * 604800000000) MICROSECOND AS `bfcol_22`
+    `bfcol_11` * 604800000000 AS `bfcol_22`
   FROM `bfcte_2`
 )
 SELECT
diff --git a/tests/unit/core/compile/sqlglot/expressions/test_unary_compiler.py b/tests/unit/core/compile/sqlglot/expressions/test_unary_compiler.py
index 815bb84a9a..fced18f5be 100644
--- a/tests/unit/core/compile/sqlglot/expressions/test_unary_compiler.py
+++ b/tests/unit/core/compile/sqlglot/expressions/test_unary_compiler.py
@@ -370,12 +370,25 @@ def test_invert(scalar_types_df: bpd.DataFrame, snapshot):
 
 
 def test_is_in(scalar_types_df: bpd.DataFrame, snapshot):
-    col_name = "int64_col"
-    bf_df = scalar_types_df[[col_name]]
-    sql = _apply_unary_ops(
-        bf_df, [ops.IsInOp(values=(1, 2, 3)).as_expr(col_name)], [col_name]
-    )
+    int_col = "int64_col"
+    float_col = "float64_col"
+    bf_df = scalar_types_df[[int_col, float_col]]
+    ops_map = {
+        "ints": ops.IsInOp(values=(1, 2, 3)).as_expr(int_col),
+        "ints_w_null": ops.IsInOp(values=(None, 123456)).as_expr(int_col),
+        "floats": ops.IsInOp(values=(1.0, 2.0, 3.0), match_nulls=False).as_expr(
+            int_col
+        ),
+        "strings": ops.IsInOp(values=("1.0", "2.0")).as_expr(int_col),
+        "mixed": ops.IsInOp(values=("1.0", 2.5, 3)).as_expr(int_col),
+        "empty": ops.IsInOp(values=()).as_expr(int_col),
+        "ints_wo_match_nulls": ops.IsInOp(
+            values=(None, 123456), match_nulls=False
+        ).as_expr(int_col),
+        "float_in_ints": ops.IsInOp(values=(1, 2, 3, None)).as_expr(float_col),
+    }
 
+    sql = _apply_unary_ops(bf_df, list(ops_map.values()), list(ops_map.keys()))
     snapshot.assert_match(sql, "out.sql")