diff --git a/noxfile.py b/noxfile.py
index 70e65a571..bc59e48a0 100644
--- a/noxfile.py
+++ b/noxfile.py
@@ -34,7 +34,7 @@
 
 MYPY_VERSION = "mypy==1.10.0"
 
-DEFAULT_PYTHON_VERSION = "3.13"
+DEFAULT_PYTHON_VERSION = "3.14"
 
 UNIT_TEST_PYTHON_VERSIONS: List[str] = [
     "3.7",
@@ -44,6 +44,7 @@
     "3.11",
     "3.12",
     "3.13",
+    "3.14",
 ]
 UNIT_TEST_STANDARD_DEPENDENCIES = [
     "mock",
@@ -60,7 +61,7 @@
 UNIT_TEST_EXTRAS: List[str] = []
 UNIT_TEST_EXTRAS_BY_PYTHON: Dict[str, List[str]] = {}
 
-SYSTEM_TEST_PYTHON_VERSIONS: List[str] = ["3.12"]
+SYSTEM_TEST_PYTHON_VERSIONS: List[str] = ["3.12", "3.14"]
 SYSTEM_TEST_STANDARD_DEPENDENCIES: List[str] = [
     "mock",
     "pytest",
@@ -436,7 +437,7 @@ def docfx(session):
     )
 
 
-@nox.session(python="3.13")
+@nox.session(python="3.14")
 @nox.parametrize(
     "protobuf_implementation",
     ["python", "upb", "cpp"],
@@ -444,7 +445,7 @@ def docfx(session):
 def prerelease_deps(session, protobuf_implementation):
     """Run all tests with prerelease versions of dependencies installed."""
 
-    if protobuf_implementation == "cpp" and session.python in ("3.11", "3.12", "3.13"):
+    if protobuf_implementation == "cpp" and session.python in ("3.11", "3.12", "3.13", "3.14"):
         session.skip("cpp implementation is not supported in python 3.11+")
 
     # Install all dependencies
diff --git a/setup.py b/setup.py
index 899cefde6..6dbea105a 100644
--- a/setup.py
+++ b/setup.py
@@ -36,7 +36,8 @@
     release_status = "Development Status :: 5 - Production/Stable"
 
 dependencies = [
-    "grpcio >= 1.51.3, < 2.0.0",  # https://github.com/googleapis/python-pubsub/issues/609
+    "grpcio >= 1.51.3, < 2.0.0; python_version < '3.14'",  # https://github.com/googleapis/python-pubsub/issues/609
+    "grpcio >= 1.75.1, < 2.0.0; python_version >= '3.14'",
     # google-api-core >= 1.34.0 is allowed in order to support google-api-core 1.x
     "google-auth >= 2.14.1, <3.0.0",
     "google-api-core[grpc] >= 1.34.0, <3.0.0,!=2.0.*,!=2.1.*,!=2.2.*,!=2.3.*,!=2.4.*,!=2.5.*,!=2.6.*,!=2.7.*,!=2.8.*,!=2.9.*,!=2.10.*",
@@ -88,6 +89,7 @@
         "Programming Language :: Python :: 3.11",
         "Programming Language :: Python :: 3.12",
         "Programming Language :: Python :: 3.13",
+        "Programming Language :: Python :: 3.14",
         "Operating System :: OS Independent",
         "Topic :: Internet",
     ],