diff --git a/CHANGELOG.rst b/CHANGELOG.rst
index 8e1fd60b..b1a00c2d 100644
--- a/CHANGELOG.rst
+++ b/CHANGELOG.rst
@@ -25,9 +25,11 @@ Fixed
 ^^^^^
 - ``set_parsing_settings(validate_defaults=True)`` fails when the parser has a
   config action (`#718 <https://github.com/omni-us/jsonargparse/pull/718>`__).
-- Regression causing dump/save to fail when ``skip_link_targets=True`` and target
-  being an entire required dataclass (`#717
+- Regression causing dump/save to fail when ``skip_link_targets=True`` and
+  target being an entire required dataclass (`#717
   <https://github.com/omni-us/jsonargparse/pull/717>`__).
+- ``TypedDict`` values not validated when types are forward references (`#722
+  <https://github.com/omni-us/jsonargparse/pull/722>`__).
 
 Changed
 ^^^^^^^
diff --git a/jsonargparse/_typehints.py b/jsonargparse/_typehints.py
index c4518ff8..c093eab5 100644
--- a/jsonargparse/_typehints.py
+++ b/jsonargparse/_typehints.py
@@ -11,11 +11,13 @@
 from copy import deepcopy
 from enum import Enum
 from functools import partial
+from importlib import import_module
 from types import FunctionType, MappingProxyType
 from typing import (
     Any,
     Callable,
     Dict,
+    ForwardRef,
     Iterable,
     List,
     Literal,
@@ -719,6 +721,15 @@ def raise_union_unexpected_value(subtypes, val: Any, exceptions: List[Exception]
     ) from exceptions[0]
 
 
+def resolve_forward_ref(ref):
+    if not isinstance(ref, ForwardRef) or not ref.__forward_module__:
+        return ref
+
+    aliases = __builtins__.copy()
+    aliases.update(vars(import_module(ref.__forward_module__)))
+    return aliases.get(ref.__forward_arg__, ref)
+
+
 def adapt_typehints(
     val,
     typehint,
@@ -954,7 +965,8 @@ def adapt_typehints(
             if extra_keys:
                 raise_unexpected_value(f"Unexpected keys: {extra_keys}", val)
             for k, v in val.items():
-                val[k] = adapt_typehints(v, typehint.__annotations__[k], **adapt_kwargs)
+                subtypehint = resolve_forward_ref(typehint.__annotations__[k])
+                val[k] = adapt_typehints(v, subtypehint, **adapt_kwargs)
         if typehint_origin is MappingProxyType and not serialize:
             val = MappingProxyType(val)
         elif typehint_origin is OrderedDict:
@@ -1100,6 +1112,11 @@ def adapt_typehints(
     elif is_alias_type(typehint):
         return adapt_typehints(val, get_alias_target(typehint), **adapt_kwargs)
 
+    else:
+        if str(typehint) == "+VT_co":
+            return val  # required for typing.Mapping in python 3.8
+        raise RuntimeError(f"The code should never reach here: typehint={typehint}")  # pragma: no cover
+
     return val
 
 
diff --git a/jsonargparse_tests/test_typehints.py b/jsonargparse_tests/test_typehints.py
index 754f52ff..0e2ac72a 100644
--- a/jsonargparse_tests/test_typehints.py
+++ b/jsonargparse_tests/test_typehints.py
@@ -753,8 +753,7 @@ def test_invalid_inherited_unpack_typeddict(parser, init_args):
         parser.parse_args([f"--testclass={json.dumps(test_config)}"])
 
 
-@pytest.mark.skipif(sys.version_info < (3, 9), reason="Python 3.8 lacked runtime inspection of TypedDict required keys")
-def test_typeddict_totality_inheritance(parser):
+if sys.version_info >= (3, 9):
 
     class BottomDict(TypedDict, total=True):
         a: int
@@ -765,6 +764,9 @@ class MiddleDict(BottomDict, total=False):
     class TopDict(MiddleDict, total=True):
         c: int
 
+
+@pytest.mark.skipif(sys.version_info < (3, 9), reason="Python 3.8 lacked runtime inspection of TypedDict required keys")
+def test_typeddict_totality_inheritance(parser):
     parser.add_argument("--middledict", type=MiddleDict, required=False)
     parser.add_argument("--topdict", type=TopDict, required=False)
     assert {"a": 1} == parser.parse_args(['--middledict={"a": 1}'])["middledict"]