diff --git a/bittensor/__init__.py b/bittensor/__init__.py
index e290570af2..6354091f2e 100644
--- a/bittensor/__init__.py
+++ b/bittensor/__init__.py
@@ -1,3 +1,10 @@
 from .core.settings import __version__, DEFAULTS, DEFAULT_NETWORK
 from .utils.btlogging import logging
+from .utils.async_substrate_interface_patch import apply_patch
+# Apply the memory leak patch for AsyncSubstrateInterface *before* importing anything
+# that may create AsyncSubstrateInterface instances. In particular, easy_imports
+# pulls in AsyncSubtensor, which uses AsyncSubstrateInterface, so it must be
+# imported only after apply_patch() has been called. Do not reorder these imports.
+apply_patch()
+
 from .utils.easy_imports import *
diff --git a/bittensor/core/async_subtensor.py b/bittensor/core/async_subtensor.py
index 6dab64e150..8801eb6e98 100644
--- a/bittensor/core/async_subtensor.py
+++ b/bittensor/core/async_subtensor.py
@@ -9481,5 +9481,9 @@ async def get_async_subtensor(
     sub = AsyncSubtensor(
         network=network, config=config, mock=mock, log_verbose=log_verbose
     )
-    await sub.initialize()
-    return sub
+    try:
+        await sub.initialize()
+        return sub
+    except Exception as e:
+        await sub.close()
+        raise
diff --git a/bittensor/utils/async_substrate_interface_patch.py b/bittensor/utils/async_substrate_interface_patch.py
new file mode 100644
index 0000000000..8767f6e52e
--- /dev/null
+++ b/bittensor/utils/async_substrate_interface_patch.py
@@ -0,0 +1,88 @@
+import weakref
+from async_substrate_interface.utils import cache
+
+
+class WeakMethodCallable:
+    """
+    A callable that holds a weak reference to a bound method.
+    Used to break reference cycles in CachedFetcher.
+    """
+
+    def __init__(self, bound_method):
+        self._weak_method = weakref.WeakMethod(bound_method)
+
+    async def __call__(self, *args, **kwargs):
+        method = self._weak_method()
+        if method is None:
+            # The underlying method/instance has been garbage collected.
+            # Return None gracefully instead of raising, so callers of
+            # CachedFetcher do not see a low-level ReferenceError.
+            return None
+        return await method(*args, **kwargs)
+
+
+def _new_get(self, instance, owner):
+    """
+    Patched __get__ method for async_substrate_interface.utils.cache._CachedFetcherMethod.
+
+    The original implementation stored a cached *bound* method in a per-instance
+    cache on _CachedFetcherMethod. Because bound methods hold a strong reference
+    to their instance, this created a reference cycle:
+
+        AsyncSubstrateInterface instance
+            -> _CachedFetcherMethod (as a descriptor on the class)
+            -> per-instance cache (a dict keyed by instance)
+            -> cached bound method
+            -> AsyncSubstrateInterface instance
+
+    As a result, AsyncSubstrateInterface instances could not be garbage-collected
+    even when no external references remained.
+
+    This patched __get__ breaks that cycle in two ways:
+      * _instances is a weakref.WeakKeyDictionary, so it does not keep instances
+        alive just because they are used as keys.
+      * The cached bound method is wrapped in WeakMethodCallable, which stores
+        only a weak reference to the underlying bound method/instance.
+
+    Combined, these changes ensure that _CachedFetcherMethod no longer holds
+    strong references that would prevent AsyncSubstrateInterface instances from
+    being garbage-collected, thereby preventing memory leaks.
+    """
+    if instance is None:
+        return self
+
+    # Migration/Safety: Ensure _instances is a WeakKeyDictionary.
+    # If it's the original dict (from before patching), replace it,
+    # preserving any existing cached instances.
+    if not isinstance(self._instances, weakref.WeakKeyDictionary):
+        self._instances = weakref.WeakKeyDictionary(self._instances)
+
+    # Cache per-instance
+    if instance not in self._instances:
+        bound_method = self.method.__get__(instance, owner)
+
+        # Use WeakMethodCallable to avoid a strong reference cycle that would otherwise be:
+        # _CachedFetcherMethod (class attr) -> WeakKeyDictionary -> CachedFetcher -> bound method -> instance.
+        # WeakMethodCallable stores a weakref.WeakMethod instead of the bound method itself, so it does not
+        # keep a strong reference to the instance and thus breaks this potential cycle.
+        wrapped_method = WeakMethodCallable(bound_method)
+
+        self._instances[instance] = cache.CachedFetcher(
+            max_size=self.max_size,
+            method=wrapped_method,
+            cache_key_index=self.cache_key_index,
+        )
+    return self._instances[instance]
+
+
+def apply_patch():
+    """
+    Applies the patch to async_substrate_interface.utils.cache._CachedFetcherMethod.
+    """
+    target_class = cache._CachedFetcherMethod
+    # Check if already patched to avoid recursion or double patching issues
+    if getattr(target_class, "_bittensor_patched", False):
+        return
+
+    target_class.__get__ = _new_get
+    target_class._bittensor_patched = True