stricter edge case checking

Author: matiaslindgren

pandas/core/frame.py

@@ -4454,8 +4454,12 @@ def _set_item_frame_value(self, key, value: DataFrame) -> None:
                 cols_droplevel = maybe_droplevels(cols, key)
                 if (
                     not isinstance(cols_droplevel, MultiIndex)
+                    and cols_droplevel.dtype.type is str
                     and not cols_droplevel.any()
                 ):
+                    # if cols_droplevel contains only empty strings,
+                    # value.reindex(cols_droplevel, axis=1) would be full of NaNs
+                    # see GH#62518 and GH#61841
                     return
                 if len(cols_droplevel) and not cols_droplevel.equals(value.columns):
                     value = value.reindex(cols_droplevel, axis=1)

pandas/tests/indexing/multiindex/test_multiindex.py

@@ -271,3 +271,12 @@ def test_multiindex_assign_aligns_as_implicit_tuple(self):
         df1["C"] = s1
         tm.assert_frame_equal(df1, df2)
         tm.assert_frame_equal(df1, df3)
+
+        # GH 62518
+        meta = DataFrame(
+            columns=MultiIndex.from_arrays(
+                [["a", "a", "z", "z"], pd.Categorical([1, 2, 1, 2])],
+            ),
+            dtype=object,
+        )
+        meta["z"] = meta["z"].astype("int64")