diff --git a/doc/source/whatsnew/v3.0.0.rst b/doc/source/whatsnew/v3.0.0.rst
index f6073e3b17e83..3dd8b8561ed8c 100644
--- a/doc/source/whatsnew/v3.0.0.rst
+++ b/doc/source/whatsnew/v3.0.0.rst
@@ -239,6 +239,7 @@ Other enhancements
 - Added a new :meth:`DataFrame.from_arrow` method to import any Arrow-compatible
   tabular data object into a pandas :class:`DataFrame` through the
   `Arrow PyCapsule Protocol <https://arrow.apache.org/docs/format/CDataInterface/PyCapsuleInterface.html>`__ (:issue:`59631`)
+- :meth:`DataFrame.itertuples` is now annotated to return an iterable of Any to accommodate dynamic namedtuple types
 
 .. ---------------------------------------------------------------------------
 .. _whatsnew_300.notable_bug_fixes:
diff --git a/pandas/core/frame.py b/pandas/core/frame.py
index 79f1c15d26ee6..9af142455a08e 100644
--- a/pandas/core/frame.py
+++ b/pandas/core/frame.py
@@ -1598,9 +1598,17 @@ def iterrows(self) -> Iterable[tuple[Hashable, Series]]:
                 s._mgr.add_references(self._mgr)
             yield k, s
 
+    @overload
+    def itertuples(self, index: bool, name: None) -> Iterable[tuple[Any, ...]]:
+        ...
+
+    @overload
+    def itertuples(self, index: bool, name: str) -> Iterable[Any]:
+        ...
+
     def itertuples(
         self, index: bool = True, name: str | None = "Pandas"
-    ) -> Iterable[tuple[Any, ...]]:
+    ) -> Iterable[tuple[Any, ...]] | Iterable[Any]:
         """
         Iterate over DataFrame rows as namedtuples.