diff --git a/Misc/NEWS.d/next/macOS/2025-12-14-15-05-10.gh-issue-142721.ZpCaPm.rst b/Misc/NEWS.d/next/macOS/2025-12-14-15-05-10.gh-issue-142721.ZpCaPm.rst
new file mode 100644
index 00000000000000..cb42da0bcb23c7
--- /dev/null
+++ b/Misc/NEWS.d/next/macOS/2025-12-14-15-05-10.gh-issue-142721.ZpCaPm.rst
@@ -0,0 +1 @@
+Corrected the macro names for conditional Apple targets.
diff --git a/Objects/mimalloc/prim/unix/prim.c b/Objects/mimalloc/prim/unix/prim.c
index 1598ebabf0a4da..1dcca1516ac4eb 100644
--- a/Objects/mimalloc/prim/unix/prim.c
+++ b/Objects/mimalloc/prim/unix/prim.c
@@ -39,7 +39,7 @@ terms of the MIT license. A copy of the license can be found in the file
   #endif
 #elif defined(__APPLE__)
   #include <TargetConditionals.h>
-  #if !TARGET_IOS_IPHONE && !TARGET_IOS_SIMULATOR
+  #if !TARGET_OS_IPHONE && !TARGET_OS_SIMULATOR
   #include <mach/vm_statistics.h>
   #endif
 #elif defined(__FreeBSD__) || defined(__DragonFly__)